Get more from you Wacom than you are now. I love mine.

Here's a question: how the heck do you clean the thing? The grime that accumulates on the mouse where it glides over the Wacom tablet makes me crazy.

Right out of the manual:

Keep your Intuos3 tools and tablet surface clean. Dust and dirt particles can stick to your tools and cause scratching and wear to the tablet’s high-gloss surface. Regular cleaning with a soft, damp cloth will help to prolong the life of your tablet surface and tools; you can also dampen the cloth using a very mild soap diluted with water. Do not use volatile liquids, such as paint thinner or benzene, because they may damage the plastic case.